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Ranolazine Decreases Mechanosensitivity of the Voltage-Gated Sodium Ion Channel Na(V)1.5: A Novel Mechanism of Drug Action
BACKGROUND: Na(V)1.5 is a mechanosensitive voltage gated sodium-selective ion channel responsible for the depolarizing current and maintenance of the action potential plateau in the heart. Ranolazine is a Na(V)1.5 antagonist with anti-anginal and anti-arrhythmic properties. METHODS AND RESULTS: Mech...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3392778/ https://ncbi.nlm.nih.gov/pubmed/22565935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.094714 |
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