Ranolazine inhibits voltage-gated mechanosensitive sodium channels in human colon circular smooth muscle cells

Human jejunum smooth muscle cells (SMCs) and interstitial cells of Cajal (ICCs) express the SCN5A-encoded voltage-gated, mechanosensitive sodium channel Na(V)1.5. Na(V)1.5 contributes to small bowel excitability, and Na(V)1.5 inhibitor ranolazine produces constipation by an unknown mechanism. We aim...

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Detalles Bibliográficos
Publicado en:Am J Physiol Gastrointest Liver Physiol
Main Authors: Neshatian, Leila, Strege, Peter R., Rhee, Poong-Lyul, Kraichely, Robert E., Mazzone, Amelia, Bernard, Cheryl E., Cima, Robert R., Larson, David W., Dozois, Eric J., Kline, Crystal F., Mohler, Peter J., Beyder, Arthur, Farrugia, Gianrico
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2015
Assuntos:
Neurogastroenterology and Motility
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572410/
https://ncbi.nlm.nih.gov/pubmed/26185330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00051.2015
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