Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased Na(V)1.5 current and mechanosensitivity

The SCN5A-encoded voltage-gated mechanosensitive Na(+) channel Na(V)1.5 is expressed in human gastrointestinal smooth muscle cells and interstitial cells of Cajal. Na(V)1.5 contributes to smooth muscle electrical slow waves and mechanical sensitivity. In predominantly Caucasian irritable bowel syndr...

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Detalles Bibliográficos
Publicado en:Am J Physiol Gastrointest Liver Physiol
Main Authors: Strege, Peter R., Mazzone, Amelia, Bernard, Cheryl E., Neshatian, Leila, Gibbons, Simon J., Saito, Yuri A., Tester, David J., Calvert, Melissa L., Mayer, Emeran A., Chang, Lin, Ackerman, Michael J., Beyder, Arthur, Farrugia, Gianrico
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2018
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966747/
https://ncbi.nlm.nih.gov/pubmed/29167113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00016.2017
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