Loss-of-function of the Voltage-gated Sodium Channel NaV1.5 (Channelopathies) in Patients with Irritable Bowel Syndrome

BACKGROUND & AIMS: SCN5A encodes the α-subunit of the voltage-gated sodium channel Na(V)1.5. Many patients with cardiac arrhythmias caused by mutations in SCN5A also have symptoms of irritable bowel syndrome (IBS). We investigated whether patients with IBS have SCN5A variants that affect the fun...

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Main Authors: Beyder, Arthur, Mazzone, Amelia, Strege, Peter R., Tester, David J., Saito, Yuri A., Bernard, Cheryl E., Enders, Felicity T., Ek, Weronica E, Schmidt, Peter T, Dlugosz, Aldona, Lindberg, Greger, Karling, Pontus, Ohlsson, Bodil, Gazouli, Maria, Nardone, Gerardo, Cuomo, Rosario, Usai-Satta, Paolo, Galeazzi, Francesca, Neri, Matteo, Portincasa, Piero, Bellini, Massimo, Barbara, Giovanni, Camilleri, Michael, Locke, G. Richard, Talley, Nicholas J., D'Amato, Mauro, Ackerman, Michael J., Farrugia, Gianrico
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096335/
https://ncbi.nlm.nih.gov/pubmed/24613995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.02.054
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