Sodium channel mutation in irritable bowel syndrome: evidence for an ion channelopathy

The SCN5A-encoded Na(v)1.5 Na(+) channel is expressed in interstitial cells of Cajal and smooth muscle in the circular layer of the human intestine. Patients with mutations in SCN5A are more likely to report gastrointestinal symptoms, especially abdominal pain. Twin and family studies of irritable b...

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Hlavní autoři: Saito, Yuri A., Strege, Peter R., Tester, David J., Locke, G. Richard, Talley, Nicholas J., Bernard, Cheryl E., Rae, James L., Makielski, Jonathan C., Ackerman, Michael J., Farrugia, Gianrico
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2009
Témata:
Neuroregulation and Motility
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643921/
https://ncbi.nlm.nih.gov/pubmed/19056759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.90571.2008
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