Sodium channel mutation in irritable bowel syndrome: evidence for an ion channelopathy

The SCN5A-encoded Na(v)1.5 Na(+) channel is expressed in interstitial cells of Cajal and smooth muscle in the circular layer of the human intestine. Patients with mutations in SCN5A are more likely to report gastrointestinal symptoms, especially abdominal pain. Twin and family studies of irritable b...

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Detalhes bibliográficos
Main Authors: Saito, Yuri A., Strege, Peter R., Tester, David J., Locke, G. Richard, Talley, Nicholas J., Bernard, Cheryl E., Rae, James L., Makielski, Jonathan C., Ackerman, Michael J., Farrugia, Gianrico
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Neuroregulation and Motility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643921/
https://ncbi.nlm.nih.gov/pubmed/19056759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.90571.2008
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