Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased Na(V)1.5 current and mechanosensitivity

The SCN5A-encoded voltage-gated mechanosensitive Na(+) channel Na(V)1.5 is expressed in human gastrointestinal smooth muscle cells and interstitial cells of Cajal. Na(V)1.5 contributes to smooth muscle electrical slow waves and mechanical sensitivity. In predominantly Caucasian irritable bowel syndr...

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Détails bibliographiques
Publié dans:Am J Physiol Gastrointest Liver Physiol
Auteurs principaux: Strege, Peter R., Mazzone, Amelia, Bernard, Cheryl E., Neshatian, Leila, Gibbons, Simon J., Saito, Yuri A., Tester, David J., Calvert, Melissa L., Mayer, Emeran A., Chang, Lin, Ackerman, Michael J., Beyder, Arthur, Farrugia, Gianrico
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966747/
https://ncbi.nlm.nih.gov/pubmed/29167113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00016.2017
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