Cardiac fibroblast-specific p38α MAP kinase promotes cardiac hypertrophy via a putative paracrine interleukin-6 signaling mechanism

Recent studies suggest that cardiac fibroblast-specific p38α MAPK contributes to the development of cardiac hypertrophy, but the underlying mechanism is unknown. Our study used a novel fibroblast-specific, tamoxifen-inducible p38α knockout (KO) mouse line to characterize the role of fibroblast p38α...

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Dettagli Bibliografici
Pubblicato in:FASEB J
Autori principali: Bageghni, Sumia A., Hemmings, Karen E., Zava, Ngonidzashe, Denton, Christopher P., Porter, Karen E., Ainscough, Justin F. X., Drinkhill, Mark J., Turner, Neil A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629170/
https://ncbi.nlm.nih.gov/pubmed/29601781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201701455RR
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