Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion

Piezo1 is a mechanosensitive cation channel with widespread physiological importance; however, its role in the heart is poorly understood. Cardiac fibroblasts help preserve myocardial integrity and play a key role in regulating its repair and remodeling following stress or injury. Here we investigat...

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Vydáno v:J Biol Chem
Hlavní autoři: Blythe, Nicola M., Muraki, Katsuhiko, Ludlow, Melanie J., Stylianidis, Vasili, Gilbert, Hamish T. J., Evans, Elizabeth L., Cuthbertson, Kevin, Foster, Richard, Swift, Joe, Li, Jing, Drinkhill, Mark J., van Nieuwenhoven, Frans A., Porter, Karen E., Beech, David J., Turner, Neil A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6873183/
https://ncbi.nlm.nih.gov/pubmed/31586031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009167
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