Yoda1 analogue (Dooku1) which antagonizes Yoda1‐evoked activation of Piezo1 and aortic relaxation

BACKGROUND AND PURPOSE: The mechanosensitive Piezo1 channel has important roles in vascular physiology and disease. Yoda1 is a small‐molecule agonist, but the pharmacology of these channels is otherwise limited. EXPERIMENTAL APPROACH: Yoda1 analogues were generated by synthetic chemistry. Intracellu...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Evans, Elizabeth L, Cuthbertson, Kevin, Endesh, Naima, Rode, Baptiste, Blythe, Nicola M, Hyman, Adam J, Hall, Sally J, Gaunt, Hannah J, Ludlow, Melanie J, Foster, Richard, Beech, David J
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913400/
https://ncbi.nlm.nih.gov/pubmed/29498036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14188
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