A mechanism for the activation of the mechanosensitive Piezo1 channel by the small molecule Yoda1

Mechanosensitive Piezo1 and Piezo2 channels transduce various forms of mechanical forces into cellular signals that play vital roles in many important biological processes in vertebrate organisms. Besides mechanical forces, Piezo1 is selectively activated by micromolar concentrations of the small mo...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Botello-Smith, Wesley M., Jiang, Wenjuan, Zhang, Han, Ozkan, Alper D., Lin, Yi-Chun, Pham, Christine N., Lacroix, Jérôme J., Luo, Yun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6776524/
https://ncbi.nlm.nih.gov/pubmed/31582801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12501-1
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