Crowding-induced opening of the mechanosensitive Piezo1 channel in silico

Mechanosensitive Piezo1 channels are essential mechanotransduction proteins in eukaryotes. Their curved transmembrane domains, called arms, create a convex membrane deformation, or footprint, which is predicted to flatten in response to increased membrane tension. Here, using a hyperbolic tangent mo...

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Pubblicato in:Commun Biol
Autori principali: Jiang, Wenjuan, Del Rosario, John Smith, Botello-Smith, Wesley, Zhao, Siyuan, Lin, Yi-chun, Zhang, Han, Lacroix, Jérôme, Rohacs, Tibor, Luo, Yun Lyna
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815867/
https://ncbi.nlm.nih.gov/pubmed/33469156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01600-1
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