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Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides

Capsaicin is an activator of the heat-sensitive TRPV1 (transient receptor potential vanilloid 1) ion channels and has been used as a local analgesic. We found that activation of TRPV1 channels with capsaicin either in dorsal root ganglion neurons or in a heterologous expression system inhibited the...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Borbiro, Istvan, Badheka, Doreen, Rohacs, Tibor
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527171/
https://ncbi.nlm.nih.gov/pubmed/25670203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005667
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