Fibroblast-specific deletion of IL-1 receptor-1 reduces adverse cardiac remodeling following myocardial infarction

It has been hypothesized that IL-1α is released from damaged cardiomyocytes following myocardial infarction (MI) and activates cardiac fibroblasts via its receptor (IL-1R1) to drive the early stages of cardiac remodeling. This study aimed to definitively test this hypothesis using cell type–specific...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Bageghni, Sumia A., Hemmings, Karen E., Yuldasheva, Nadira Y., Maqbool, Azhar, Gamboa-Esteves, Filomena O., Humphreys, Neil E., Jackson, Maj Simonsen, Denton, Christopher P., Francis, Sheila, Porter, Karen E., Ainscough, Justin F.X., Pinteaux, Emmanuel, Drinkhill, Mark J., Turner, Neil A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6777910/
https://ncbi.nlm.nih.gov/pubmed/31393855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125074
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