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Cardiomyocyte­-specific expression of the nuclear matrix protein, CIZ1, stimulates production of mono-nucleated cells with an extended window of proliferation in the postnatal mouse heart

Myocardial injury in mammals leads to heart failure through pathological cardiac remodelling that includes hypertrophy, fibrosis and ventricular dilatation. Central to this is inability of the mammalian cardiomyocyte to self-renew due to entering a quiescent state after birth. Modulation of the card...

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Vydáno v:Biol Open
Hlavní autoři: Bageghni, Sumia A., Frentzou, Georgia A., Drinkhill, Mark J., Mansfield, William, Coverley, Dawn, Ainscough, Justin F. X.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278428/
https://ncbi.nlm.nih.gov/pubmed/27934662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.021550
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