A glucose-dependent spatial patterning of exocytosis in human β cells is disrupted in type 2 diabetes

Impaired insulin secretion in type 2 diabetes (T2D) is linked to reduced insulin granule docking, disorganization of the exocytotic site, and impaired glucose-dependent facilitation of insulin exocytosis. We show in β cells from 80 human donors that the glucose-dependent amplification of exocytosis...

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Détails bibliographiques
Publié dans:JCI Insight
Auteurs principaux: Fu, Jianyang, Githaka, John Maringa, Dai, Xiaoqing, Plummer, Gregory, Suzuki, Kunimasa, Spigelman, Aliya F., Bautista, Austin, Kim, Ryekjang, Greitzer-Antes, Dafna, Fox, Jocelyn E. Manning, Gaisano, Herbert Y., MacDonald, Patrick E.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629118/
https://ncbi.nlm.nih.gov/pubmed/31085831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127896
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