Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation

Th1 and Th17 are important in the pathogenesis of autoimmune diseases and they depend on glycolysis as a source of energy. T cell antigen receptor signaling phosphorylates a serine/threonine kinase, calcium/calmodulin–dependent protein kinase IV (CaMK4), and promotes glycolysis. Based on these findi...

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Udgivet i:JCI Insight
Main Authors: Kono, Michihito, Maeda, Kayaho, Stocton-Gavanescu, Irina, Pan, Wenliang, Umeda, Masataka, Katsuyama, Eri, Burbano, Catalina, Orite, Seo Yeon K., Vukelic, Milena, Tsokos, Maria G., Yoshida, Nobuya, Tsokos, George C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629104/
https://ncbi.nlm.nih.gov/pubmed/31217348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127395
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