ICER is requisite for Th17 differentiation

Inducible cAMP early repressor (ICER) has been described as a transcriptional repressor isoform of the cAMP response element modulator (CREM). Here we report that ICER is predominantly expressed in Th17 cells through the IL-6–STAT3 pathway and binds to the Il17a promoter, where it facilitates the ac...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Yoshida, Nobuya, Comte, Denis, Mizui, Masayuki, Otomo, Kotaro, Rosetti, Florencia, Mayadas, Tanya N., Crispín, José C., Bradley, Sean J., Koga, Tomohiro, Kono, Michihito, Karampetsou, Maria P., Kyttaris, Vasileios C., Tenbrock, Klaus, Tsokos, George C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056420/
https://ncbi.nlm.nih.gov/pubmed/27680869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12993
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