KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3(+) regulatory T cells in MRL/lpr mice

OBJECTIVE: Foxp3(+) regulatory T cells (T(reg)) are pivotal for the maintenance of peripheral tolerance and prevent development of autoimmune diseases. We have reported that calcium/calmodulin-dependent protein kinase IV (CaMK4) deficient MRL/lpr mice display less disease activity by promoting IL-2...

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Detalhes bibliográficos
Publicado no:Autoimmunity
Main Authors: Koga, Tomohiro, Mizui, Masayuki, Yoshida, Nobuya, Otomo, Kotaro, Lieberman, Linda A., Crispín, José C., Tsokos, George C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4341833/
https://ncbi.nlm.nih.gov/pubmed/24829059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/08916934.2014.915954
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