CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance

Tissue inflammation in several autoimmune diseases, including SLE and MS, has been linked to an imbalance of IL-17–producing Th (Th17) cells and Tregs; however, the factors that promote Th17-driven autoimmunity are unclear. Here, we present evidence that the calcium/calmodulin-dependent protein kina...

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Bibliographic Details
Main Authors: Koga, Tomohiro, Hedrich, Christian M., Mizui, Masayuki, Yoshida, Nobuya, Otomo, Kotaro, Lieberman, Linda A., Rauen, Thomas, Crispín, José C., Tsokos, George C.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001553/
https://ncbi.nlm.nih.gov/pubmed/24667640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73411
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