Glutaminase 1 Inhibition Reduces Glycolysis and Ameliorates Lupus-like Disease in MRL/lpr Mice and Experimental Autoimmune Encephalomyelitis

OBJECTIVE. Glutaminase 1 (Gls1) is the first enzyme in glutaminolysis. The selective Gls1 inhibitor Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) suppresses Th17 development and ameliorates experimental autoimmune encephalomyelitis (EAE). However, whether inhibition of glutami...

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Bibliografiske detaljer
Udgivet i:Arthritis Rheumatol
Main Authors: Kono, Michihito, Yoshida, Nobuya, Maeda, Kayaho, Suárez-Fueyo, Abel, Kyttaris, Vasileios C., Tsokos, George C.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6817384/
https://ncbi.nlm.nih.gov/pubmed/31233276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.41019
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