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Signal Transducer and Activator of Transcription (STAT) 3 Inhibition Delays The Onset Of Lupus Nephritis In MRL/lpr Mice

The transcription factor STAT3 is overexpressed and hyperactivated in T cells from SLE patients. STAT3 plays a central role in T cell differentiation into Th17 and T follicular helper cells, two subsets that orchestrate autoimmune responses in SLE. Moreover, STAT3 is important in chemokine-mediated...

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Библиографические подробности
Опубликовано в: :Clin Immunol
Главные авторы: Edwards, Lindsay J., Mizui, Masayuki, Kyttaris, Vasileios
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465043/
https://ncbi.nlm.nih.gov/pubmed/25869298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2015.04.004
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