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Signal Transducer and Activator of Transcription (STAT) 3 Inhibition Delays The Onset Of Lupus Nephritis In MRL/lpr Mice
The transcription factor STAT3 is overexpressed and hyperactivated in T cells from SLE patients. STAT3 plays a central role in T cell differentiation into Th17 and T follicular helper cells, two subsets that orchestrate autoimmune responses in SLE. Moreover, STAT3 is important in chemokine-mediated...
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| Publicado no: | Clin Immunol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4465043/ https://ncbi.nlm.nih.gov/pubmed/25869298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2015.04.004 |
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