DL5050, a Selective Agonist for the Human Constitutive Androstane Receptor

[Image: see text] The constitutive androstane receptor (CAR) is a xenobiotic sensor governing the transcription of genes involved in drug disposition, energy homeostasis, and cell proliferation. However, currently available human CAR (hCAR) agonists are nonselective, which commonly activate hCAR alo...

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Bibliografiske detaljer
Udgivet i:ACS Med Chem Lett
Main Authors: Liang, Dongdong, Li, Linhao, Lynch, Caitlin, Diethelm-Varela, Benjamin, Xia, Menghang, Xue, Fengtian, Wang, Hongbing
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2019
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6627732/
https://ncbi.nlm.nih.gov/pubmed/31312405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00079
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