Genomic Profiling of KRAS/NRAS/BRAF/PIK3CA Wild-Type Metastatic Colorectal Cancer Patients Reveals Novel Mutations in Genes Potentially Associated with Resistance to Anti-EGFR Agents

Previous findings suggest that metastatic colorectal carcinoma (mCRC) patients with KRAS/NRAS/BRAF/PIK3CA wild-type (quadruple-wt) tumors are highly sensitive to anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (MoAbs). However, additional molecular alterations might be involved in...

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Publicat a:Cancers (Basel)
Autors principals: Rachiglio, Anna Maria, Lambiase, Matilde, Fenizia, Francesca, Roma, Cristin, Cardone, Claudia, Iannaccone, Alessia, De Luca, Antonella, Carotenuto, Marianeve, Frezzetti, Daniela, Martinelli, Erika, Maiello, Evaristo, Ciardiello, Fortunato, Normanno, Nicola
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6627713/
https://ncbi.nlm.nih.gov/pubmed/31226844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11060859
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