Clinicopathological features and prognostic roles of KRAS, BRAF, PIK3CA and NRAS mutations in advanced gastric cancer

BACKGROUND: RAS-RAF-MEK-ERK and PI3K-AKT pathways form a significant cascade for potential molecular target therapy in advanced cancer. The clinical significance of mutations in these genes in advanced gastric cancer (AGC) is uncertain. METHODS: We collected formalin-fixed, paraffin-embedded and fre...

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Detalhes bibliográficos
Main Authors: Takahashi, Naoki, Yamada, Yasuhide, Taniguchi, Hirokazu, Fukahori, Masaru, Sasaki, Yusuke, Shoji, Hirokazu, Honma, Yoshitaka, Iwasa, Satoru, Takashima, Atsuo, Kato, Ken, Hamaguchi, Tetsuya, Shimada, Yasuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012089/
https://ncbi.nlm.nih.gov/pubmed/24774510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-7-271
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