PTPN3 acts as a tumor suppressor and boosts TGF‐β signaling independent of its phosphatase activity

TGF‐β controls a variety of cellular functions during development. Abnormal TGF‐β responses are commonly found in human diseases such as cancer, suggesting that TGF‐β signaling must be tightly regulated. Here, we report that protein tyrosine phosphatase non‐receptor 3 (PTPN3) profoundly potentiates...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO J
Prif Awduron: Yuan, Bo, Liu, Jinquan, Cao, Jin, Yu, Yi, Zhang, Hanchenxi, Wang, Fei, Zhu, Yezhang, Xiao, Mu, Liu, Sisi, Ye, Youqiong, Ma, Le, Xu, Dewei, Xu, Ningyi, Li, Yi, Zhao, Bin, Xu, Pinglong, Jin, Jianping, Xu, Jianming, Chen, Xi, Shen, Li, Lin, Xia, Feng, Xin‐Hua
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2019
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6627230/
https://ncbi.nlm.nih.gov/pubmed/31304624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899945
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