17β-Estradiol protects against interleukin-1β-induced apoptosis in rat nucleus pulposus cells via the mTOR/caspase-3 pathway

Intervertebral disc degeneration (IVDD) is the main pathological basis of spinal degenerative diseases, and aberrant apoptosis of nucleus pulposus cells (NPCs) is the main cellular process that causes IVDD. In our previous studies, 17β-estradiol (E(2)) was demonstrated to protect rat NPCs from inter...

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Detalhes bibliográficos
Publicado no:Mol Med Rep
Main Authors: Guo, Hong-Tao, Yang, Si-Dong, Zhang, Feng, Liu, Sen, Yang, Da-Long, Ma, Lei, Wang, Hui, Ding, Wen-Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6625415/
https://ncbi.nlm.nih.gov/pubmed/31257459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2019.10384
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