Protective role of 17β-estradiol on tumor necrosis factor-α-induced apoptosis in human nucleus pulposus cells

The molecular mechanisms underlying protection and pathogenesis in spinal degenerative diseases remain unclear. Tumor necrosis factor-α (TNF-α) has been demonstrated to induce apoptosis of intervertebral disc (IVD) cells during IVD degeneration, and 17β-estradiol (17β-E2) has a protective effect aga...

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Bibliographic Details
Published in:Mol Med Rep
Main Authors: Liu, Huan, Yang, Si-Dong, Xu, Ying, Ning, Sheng-Hua, Wang, Tao, Yang, Da-Long, Ding, Wen-Yuan
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2017
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561935/
https://ncbi.nlm.nih.gov/pubmed/28586025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2017.6690
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