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Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC

The AAA+ GTPase McrB powers DNA cleavage by the endonuclease McrC. The GTPase itself is activated by McrC. The architecture of the GTPase and nuclease complex, and the mechanism of their activation remained unknown. Here, we report a 3.6 Å structure of a GTPase-active and DNA-binding deficient const...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Nirwan, Neha, Itoh, Yuzuru, Singh, Pratima, Bandyopadhyay, Sutirtha, Vinothkumar, Kutti R., Amunts, Alexey, Saikrishnan, Kayarat
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624300/
https://ncbi.nlm.nih.gov/pubmed/31296862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11084-1
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