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Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC

The AAA+ GTPase McrB powers DNA cleavage by the endonuclease McrC. The GTPase itself is activated by McrC. The architecture of the GTPase and nuclease complex, and the mechanism of their activation remained unknown. Here, we report a 3.6 Å structure of a GTPase-active and DNA-binding deficient const...

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Pubblicato in:Nat Commun
Autori principali: Nirwan, Neha, Itoh, Yuzuru, Singh, Pratima, Bandyopadhyay, Sutirtha, Vinothkumar, Kutti R., Amunts, Alexey, Saikrishnan, Kayarat
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624300/
https://ncbi.nlm.nih.gov/pubmed/31296862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11084-1
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