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Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC
The AAA+ GTPase McrB powers DNA cleavage by the endonuclease McrC. The GTPase itself is activated by McrC. The architecture of the GTPase and nuclease complex, and the mechanism of their activation remained unknown. Here, we report a 3.6 Å structure of a GTPase-active and DNA-binding deficient const...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6624300/ https://ncbi.nlm.nih.gov/pubmed/31296862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11084-1 |
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