Epigenetic Segregation of Microbial Genomes from Complex Samples Using Restriction Endonucleases HpaII and McrB

We describe continuing work to develop restriction endonucleases as tools to enrich targeted genomes of interest from diverse populations. Two approaches were developed in parallel to segregate genomic DNA based on cytosine methylation. First, the methyl-sensitive endonuclease HpaII was used to bind...

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Pubblicato in:PLoS One
Autori principali: Liu, Guohong, Weston, Christopher Q., Pham, Long K., Waltz, Shannon, Barnes, Helen, King, Paula, Sphar, Dan, Yamamoto, Robert T., Forsyth, R. Allyn
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699840/
https://ncbi.nlm.nih.gov/pubmed/26727463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146064
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