Hexameric assembly of the AAA+ protein McrB is necessary for GTPase activity

McrBC is one of the three modification-dependent restriction enzymes encoded by the Escherichia coli K12 chromosome. Amongst restriction enzymes, McrBC and its close homologues are unique in employing the AAA+ domain for GTP hydrolysis-dependent activation of DNA cleavage. The GTPase activity of Mcr...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Nirwan, Neha, Singh, Pratima, Mishra, Gyana Gourab, Johnson, Christopher M, Szczelkun, Mark D, Inoue, Katsuaki, Vinothkumar, Kutti R, Saikrishnan, Kayarat
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344862/
https://ncbi.nlm.nih.gov/pubmed/30521042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1170
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