Mutant PKCγ in Spinocerebellar Ataxia Type 14 Disrupts Synapse Elimination and Long-Term Depression in Purkinje Cells In Vivo

Cerebellar Purkinje cells (PCs) express a large amount of the γ isoform of protein kinase C (PKCγ) and a modest level of PKCα. The PKCγ is involved in the pruning of climbing fiber (CF) synapses from developing PCs, and PKCα plays a critical role in long-term depression (LTD) at parallel fiber (PF)-...

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Publicado no:J Neurosci
Main Authors: Shuvaev, Anton N., Horiuchi, Hajime, Seki, Takahiro, Goenawan, Hanna, Irie, Tomohiko, Iizuka, Akira, Sakai, Norio, Hirai, Hirokazu
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6623654/
https://ncbi.nlm.nih.gov/pubmed/21976518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5530-10.2011
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