Effect of Trehalose on the Properties of Mutant γPKC, Which Causes Spinocerebellar Ataxia Type 14, in Neuronal Cell Lines and Cultured Purkinje Cells

Several missense mutations in the protein kinase Cγ (γPKC) gene have been found to cause spinocerebellar ataxia type 14 (SCA14), an autosomal dominant neurodegenerative disease. We previously demonstrated that the mutant γPKC found in SCA14 is susceptible to aggregation, which induces apoptotic cell...

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Detalhes bibliográficos
Main Authors: Seki, Takahiro, Abe-Seki, Nana, Kikawada, Takahiro, Takahashi, Hideyuki, Yamamoto, Kazuhiro, Adachi, Naoko, Tanaka, Shigeru, Hide, Izumi, Saito, Naoaki, Sakai, Norio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963337/
https://ncbi.nlm.nih.gov/pubmed/20705605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.146704
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