Deregulation of the actin cytoskeleton and macropinocytosis in response to phorbol ester by the mutant protein kinase C gamma that causes spinocerebellar ataxia type 14

Several missense mutations in the protein kinase Cγ (γPKC) gene have been found to cause spinocerebellar ataxia type 14 (SCA14), an autosomal dominant neurodegenerative disease. γPKC is a neuron-specific member of the classical PKCs and is activated and translocated to subcellular regions as a resul...

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Détails bibliographiques
Auteurs principaux: Yamamoto, Kazuhiro, Seki, Takahiro, Yamamoto, Hikaru, Adachi, Naoko, Tanaka, Shigeru, Hide, Izumi, Saito, Naoaki, Sakai, Norio
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2014
Sujets:
Physiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978357/
https://ncbi.nlm.nih.gov/pubmed/24744737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2014.00126
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