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Abnormal Regenerative Responses and Impaired Axonal Outgrowth after Nerve Crush in TDP-43 Transgenic Mouse Models of Amyotrophic Lateral Sclerosis

Tar DNA binding protein 43 (TDP-43) mislocalization and aggregation is a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia. Moreover, TDP-43 mRNA was found to be upregulated by ∼2.5-fold in the spinal cord of sporadic ALS subjects. Here we have examined the effects of...

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Dettagli Bibliografici
Pubblicato in:J Neurosci
Autori principali: Swarup, Vivek, Audet, Jean-Nicolas, Phaneuf, Daniel, Kriz, Jasna, Julien, Jean-Pierre
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6621743/
https://ncbi.nlm.nih.gov/pubmed/23238732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2267-12.2012
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