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The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease specifically affecting cortical and spinal motor neurons. Cytoplasmic inclusions containing hyperphosphorylated and ubiquitinated TDP-43 are a pathological hallmark of ALS, and mutations in the gene encoding TDP-43 have been directly...

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Bibliographic Details
Main Authors: Fallini, Claudia, Bassell, Gary J., Rossoll, Wilfried
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406762/
https://ncbi.nlm.nih.gov/pubmed/22641816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds205
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