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The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease specifically affecting cortical and spinal motor neurons. Cytoplasmic inclusions containing hyperphosphorylated and ubiquitinated TDP-43 are a pathological hallmark of ALS, and mutations in the gene encoding TDP-43 have been directly...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3406762/ https://ncbi.nlm.nih.gov/pubmed/22641816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds205 |
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