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Induction of autophagy mitigates TDP-43 pathology and translational repression of neurofilament mRNAs in mouse models of ALS/FTD

BACKGROUND: TDP-43 proteinopathy is a pathological hallmark of many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). So far, there is no therapy available for these neurodegenerative diseases. In addition, the impact of TDP-43 proteinopathy...

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Dades bibliogràfiques
Publicat a:Mol Neurodegener
Autors principals: Kumar, Sunny, Phaneuf, Daniel, Cordeau, Pierre, Boutej, Hejer, Kriz, Jasna, Julien, Jean-Pierre
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7792109/
https://ncbi.nlm.nih.gov/pubmed/33413517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00420-5
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