Induction of autophagy mitigates TDP-43 pathology and translational repression of neurofilament mRNAs in mouse models of ALS/FTD

BACKGROUND: TDP-43 proteinopathy is a pathological hallmark of many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). So far, there is no therapy available for these neurodegenerative diseases. In addition, the impact of TDP-43 proteinopathy...

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Vydáno v:Mol Neurodegener
Hlavní autoři: Kumar, Sunny, Phaneuf, Daniel, Cordeau, Pierre, Boutej, Hejer, Kriz, Jasna, Julien, Jean-Pierre
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7792109/
https://ncbi.nlm.nih.gov/pubmed/33413517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00420-5
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