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TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD

Cytoplasmic aggregation of TDP-43, accompanied by its nuclear clearance, is a key common pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD). However, a limited understanding of this RNA-binding protein (RBP) impedes the clarification of pathogenic mechanisms...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Science
Prif Awduron: Ling, Jonathan P., Pletnikova, Olga, Troncoso, Juan C., Wong, Philip C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825810/
https://ncbi.nlm.nih.gov/pubmed/26250685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aab0983
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