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TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD
Cytoplasmic aggregation of TDP-43, accompanied by its nuclear clearance, is a key common pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD). However, a limited understanding of this RNA-binding protein (RBP) impedes the clarification of pathogenic mechanisms...
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| Publicado no: | Science |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4825810/ https://ncbi.nlm.nih.gov/pubmed/26250685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aab0983 |
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