Cryptic Exon Incorporation Occurs in Alzheimer’s Brain lacking TDP-43 Inclusion but Exhibiting Nuclear Clearance of TDP-43

Abnormal accumulation of TDP-43 into cytoplasmic or nuclear inclusions with accompanying nuclear clearance, a common pathology initially identified in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), has also been found in Alzheimer’ disease (AD). TDP-43 serves as a splicing re...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Sun, Mingkuan, Bell, William, LaClair, Katherine D., Ling, Jonathan P., Han, Heather, Kageyama, Yusuke, Pletnikova, Olga, Troncoso, Juan C., Wong, Philip C., Chen, Liam L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444385/
https://ncbi.nlm.nih.gov/pubmed/28332094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-017-1701-2
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