Opposing Roles of Synaptic and Extrasynaptic NMDA Receptor Signaling in Cocultured Striatal and Cortical Neurons

The NMDAR plays a unique and vital role in subcellular signaling. Calcium influx initiates signaling cascades important for both synaptic plasticity and survival; however, overactivation of the receptor leads to toxicity and cell death. This dichotomy is partially explained by the subcellular locati...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Kaufman, Alexandra M., Milnerwood, Austen J., Sepers, Marja D., Coquinco, Ainsley, She, Kevin, Wang, Liang, Lee, Hwan, Craig, Ann Marie, Cynader, Max, Raymond, Lynn A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2012
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6621208/
https://ncbi.nlm.nih.gov/pubmed/22442066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4129-11.2012
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