Extracellular histones induce calcium signals in the endothelium of resistance-sized mesenteric arteries and cause loss of endothelium-dependent dilation

Histone proteins are elevated in the circulation after traumatic injury owing to cellular lysis and release from neutrophils. Elevated circulating histones in trauma contribute to coagulopathy and mortality through a mechanism suspected to involve endothelial cell (EC) dysfunction. However, the func...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Collier, Daniel M., Villalba, Nuria, Sackheim, Adrian, Bonev, Adrian D., Miller, Zachary D., Moore, Jesse S., Shui, Bo, Lee, Jane C., Lee, Frank K., Reining, Shaun, Kotlikoff, Michael I., Nelson, Mark T., Freeman, Kalev
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620684/
https://ncbi.nlm.nih.gov/pubmed/30848676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00655.2018
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