Extracellular histones induce calcium signals in the endothelium of resistance-sized mesenteric arteries and cause loss of endothelium-dependent dilation

Histone proteins are elevated in the circulation after traumatic injury owing to cellular lysis and release from neutrophils. Elevated circulating histones in trauma contribute to coagulopathy and mortality through a mechanism suspected to involve endothelial cell (EC) dysfunction. However, the func...

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Vydáno v:Am J Physiol Heart Circ Physiol
Hlavní autoři: Collier, Daniel M., Villalba, Nuria, Sackheim, Adrian, Bonev, Adrian D., Miller, Zachary D., Moore, Jesse S., Shui, Bo, Lee, Jane C., Lee, Frank K., Reining, Shaun, Kotlikoff, Michael I., Nelson, Mark T., Freeman, Kalev
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620684/
https://ncbi.nlm.nih.gov/pubmed/30848676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00655.2018
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