Extracellular histones induce calcium signals in the endothelium of resistance-sized mesenteric arteries and cause loss of endothelium-dependent dilation

Histone proteins are elevated in the circulation after traumatic injury owing to cellular lysis and release from neutrophils. Elevated circulating histones in trauma contribute to coagulopathy and mortality through a mechanism suspected to involve endothelial cell (EC) dysfunction. However, the func...

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Pubblicato in:Am J Physiol Heart Circ Physiol
Autori principali: Collier, Daniel M., Villalba, Nuria, Sackheim, Adrian, Bonev, Adrian D., Miller, Zachary D., Moore, Jesse S., Shui, Bo, Lee, Jane C., Lee, Frank K., Reining, Shaun, Kotlikoff, Michael I., Nelson, Mark T., Freeman, Kalev
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620684/
https://ncbi.nlm.nih.gov/pubmed/30848676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00655.2018
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