Traumatic Brain Injury Causes Endothelial Dysfunction in the Systemic Microcirculation through Arginase-1–Dependent Uncoupling of Endothelial Nitric Oxide Synthase

Endothelial dysfunction is a hallmark of many chronic diseases, including diabetes and long-term hypertension. We show that acute traumatic brain injury (TBI) leads to endothelial dysfunction in rat mesenteric arteries. Endothelial-dependent dilation was greatly diminished 24 h after TBI because of...

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Detalhes bibliográficos
Publicado no:J Neurotrauma
Main Authors: Villalba, Nuria, Sackheim, Adrian M., Nunez, Ivette A., Hill-Eubanks, David C., Nelson, Mark T., Wellman, George C., Freeman, Kalev
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198065/
https://ncbi.nlm.nih.gov/pubmed/26757855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2015.4340
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