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Extracellular histones induce calcium signals in the endothelium of resistance-sized mesenteric arteries and cause loss of endothelium-dependent dilation
Histone proteins are elevated in the circulation after traumatic injury owing to cellular lysis and release from neutrophils. Elevated circulating histones in trauma contribute to coagulopathy and mortality through a mechanism suspected to involve endothelial cell (EC) dysfunction. However, the func...
Enregistré dans:
| Publié dans: | Am J Physiol Heart Circ Physiol |
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| Auteurs principaux: | , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Physiological Society
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6620684/ https://ncbi.nlm.nih.gov/pubmed/30848676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00655.2018 |
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