Extracellular histones induce calcium signals in the endothelium of resistance-sized mesenteric arteries and cause loss of endothelium-dependent dilation

Histone proteins are elevated in the circulation after traumatic injury owing to cellular lysis and release from neutrophils. Elevated circulating histones in trauma contribute to coagulopathy and mortality through a mechanism suspected to involve endothelial cell (EC) dysfunction. However, the func...

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Détails bibliographiques
Publié dans:Am J Physiol Heart Circ Physiol
Auteurs principaux: Collier, Daniel M., Villalba, Nuria, Sackheim, Adrian, Bonev, Adrian D., Miller, Zachary D., Moore, Jesse S., Shui, Bo, Lee, Jane C., Lee, Frank K., Reining, Shaun, Kotlikoff, Michael I., Nelson, Mark T., Freeman, Kalev
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620684/
https://ncbi.nlm.nih.gov/pubmed/30848676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00655.2018
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