Extracellular histones induce calcium signals in the endothelium of resistance-sized mesenteric arteries and cause loss of endothelium-dependent dilation

Histone proteins are elevated in the circulation after traumatic injury owing to cellular lysis and release from neutrophils. Elevated circulating histones in trauma contribute to coagulopathy and mortality through a mechanism suspected to involve endothelial cell (EC) dysfunction. However, the func...

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Dades bibliogràfiques
Publicat a:Am J Physiol Heart Circ Physiol
Autors principals: Collier, Daniel M., Villalba, Nuria, Sackheim, Adrian, Bonev, Adrian D., Miller, Zachary D., Moore, Jesse S., Shui, Bo, Lee, Jane C., Lee, Frank K., Reining, Shaun, Kotlikoff, Michael I., Nelson, Mark T., Freeman, Kalev
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620684/
https://ncbi.nlm.nih.gov/pubmed/30848676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00655.2018
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