Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML

The key myeloid transcription factor (TF), CEBPA, is frequently mutated in acute myeloid leukemia (AML), but the direct molecular effects of this leukemic driver mutation remain elusive. To investigate CEBPA mutant AML, we performed microscale, in vivo chromatin immunoprecipitation sequencing and id...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Adv
Auteurs principaux: Jakobsen, Janus S., Laursen, Linea G., Schuster, Mikkel B., Pundhir, Sachin, Schoof, Erwin, Ge, Ying, d’Altri, Teresa, Vitting-Seerup, Kristoffer, Rapin, Nicolas, Gentil, Coline, Jendholm, Johan, Theilgaard-Mönch, Kim, Reckzeh, Kristian, Bullinger, Lars, Döhner, Konstanze, Hokland, Peter, Fitzgibbon, Jude, Porse, Bo T.
Format: Artigo
Langue:Inglês
Publié: American Association for the Advancement of Science 2019
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620102/
https://ncbi.nlm.nih.gov/pubmed/31309149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw4304
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