Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML

The key myeloid transcription factor (TF), CEBPA, is frequently mutated in acute myeloid leukemia (AML), but the direct molecular effects of this leukemic driver mutation remain elusive. To investigate CEBPA mutant AML, we performed microscale, in vivo chromatin immunoprecipitation sequencing and id...

詳細記述

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書誌詳細
出版年:Sci Adv
主要な著者: Jakobsen, Janus S., Laursen, Linea G., Schuster, Mikkel B., Pundhir, Sachin, Schoof, Erwin, Ge, Ying, d’Altri, Teresa, Vitting-Seerup, Kristoffer, Rapin, Nicolas, Gentil, Coline, Jendholm, Johan, Theilgaard-Mönch, Kim, Reckzeh, Kristian, Bullinger, Lars, Döhner, Konstanze, Hokland, Peter, Fitzgibbon, Jude, Porse, Bo T.
フォーマット: Artigo
言語:Inglês
出版事項: American Association for the Advancement of Science 2019
主題:
Research Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620102/
https://ncbi.nlm.nih.gov/pubmed/31309149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw4304
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