Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML

The key myeloid transcription factor (TF), CEBPA, is frequently mutated in acute myeloid leukemia (AML), but the direct molecular effects of this leukemic driver mutation remain elusive. To investigate CEBPA mutant AML, we performed microscale, in vivo chromatin immunoprecipitation sequencing and id...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Sci Adv
Main Authors: Jakobsen, Janus S., Laursen, Linea G., Schuster, Mikkel B., Pundhir, Sachin, Schoof, Erwin, Ge, Ying, d’Altri, Teresa, Vitting-Seerup, Kristoffer, Rapin, Nicolas, Gentil, Coline, Jendholm, Johan, Theilgaard-Mönch, Kim, Reckzeh, Kristian, Bullinger, Lars, Döhner, Konstanze, Hokland, Peter, Fitzgibbon, Jude, Porse, Bo T.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Association for the Advancement of Science 2019
נושאים:
Research Articles
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620102/
https://ncbi.nlm.nih.gov/pubmed/31309149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw4304
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