Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML

The key myeloid transcription factor (TF), CEBPA, is frequently mutated in acute myeloid leukemia (AML), but the direct molecular effects of this leukemic driver mutation remain elusive. To investigate CEBPA mutant AML, we performed microscale, in vivo chromatin immunoprecipitation sequencing and id...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Jakobsen, Janus S., Laursen, Linea G., Schuster, Mikkel B., Pundhir, Sachin, Schoof, Erwin, Ge, Ying, d’Altri, Teresa, Vitting-Seerup, Kristoffer, Rapin, Nicolas, Gentil, Coline, Jendholm, Johan, Theilgaard-Mönch, Kim, Reckzeh, Kristian, Bullinger, Lars, Döhner, Konstanze, Hokland, Peter, Fitzgibbon, Jude, Porse, Bo T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620102/
https://ncbi.nlm.nih.gov/pubmed/31309149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw4304
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