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Cellular response to moderate chromatin architectural defects promotes longevity
Changes in chromatin organization occur during aging. Overexpression of histones partially alleviates these changes and promotes longevity. We report that deletion of the histone H3-H4 minor locus HHT1-HHF1 extended the replicative life span of Saccharomyces cerevisiae. This longevity effect was med...
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| 出版年: | Sci Adv |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Association for the Advancement of Science
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6620092/ https://ncbi.nlm.nih.gov/pubmed/31309140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav1165 |
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