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Cellular response to moderate chromatin architectural defects promotes longevity

Changes in chromatin organization occur during aging. Overexpression of histones partially alleviates these changes and promotes longevity. We report that deletion of the histone H3-H4 minor locus HHT1-HHF1 extended the replicative life span of Saccharomyces cerevisiae. This longevity effect was med...

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Bibliografski detalji
Izdano u:Sci Adv
Glavni autori: Yu, Ruofan, Sun, Luyang, Sun, Yu, Han, Xin, Qin, Lidong, Dang, Weiwei
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2019
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620092/
https://ncbi.nlm.nih.gov/pubmed/31309140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav1165
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